iPGell
Xenogeneic-Free Human Intestinal Organoids for Assessing Intestinal Nutrient Absorption
Makoto Inoue, Yuichi Tanaka, Sakiko Matsushita, Yuri Shimozaki, Hirohito Ayame and Hidenori Akutsu
Targeting Asparagine Synthetase in Tumorgenicity Using Patient-Derived Tumor-Initiating Cells
Gen Nishikawa, Kenji Kawada, Keita Hanada, Hisatsugu Maekawa, Yoshiro Itatani, Hiroyuki Miyoshi, Makoto Mark Taketo and Kazutaka Obama
Establishment of experimental salivary gland cancer models using organoid culture and patient-derived xenografting
Yoshihiro Aizawa, Kentaro Takada, Jun Aoyama, Daisuke Sano, Shoji Yamanaka, Masahide Seki, Yuta Kuze, Jordan A. Ramilowski, Ryo Okuda, Yasuharu Ueno, Yusuke Nojima, Yoshiaki Inayama, Hiromitsu Hatakeyama, Takashi Hatano, Hideaki Takahashi, Goshi Nishimura, Satoshi Fujii, Yutaka Suzuki, Hideki Taniguchi & Nobuhiko Oridate
Cellular Oncology volume 46, pages 409–421 (2023)
Cryopreserved Spontaneous Spheroids from Compact Bone-Derived Mesenchymal Stromal Cells for Bone Tissue Engineering
Hongwei Dong, Xianqi Li, Kai Chen, Ni Li, and Hideaki Kagami
Tissue Engineering Part C: MethodsVol. 27, No. 4, 2021
Establishment and characterization of NCC-MFS4-C1: a novel patient-derived cell line of myxofibrosarcoma
Yuki Yoshimatsu, Rei Noguchi, Ryuto Tsuchiya, Yooksil Sin, Takuya Ono, Jun Sugaya, Shintaro Iwata, Akihiko Yoshida, Akira Kawai & Tadashi Kondo
Human Cell volume 34, pages 1911–1918 (2021)
Establishment and characterization of NCC-MFS4-C1: a novel patient-derived cell line of myxofibrosarcoma
Yuki Yoshimatsu, Rei Noguchi, Ryuto Tsuchiya, Yooksil Sin, Takuya Ono, Jun Sugaya, Shintaro Iwata, Akihiko Yoshida, Akira Kawai & Tadashi Kondo
Human Cell volume 34, pages 1911–1918 (2021)
Restoration of keratinocytic phenotypes in autonomous trisomy-rescued cells
Akiko Tanuma-Takahashi, Momoko Inoue, Kazuhiro Kajiwara, Ryo Takagi, Ayumi Yamaguchi, Osamu Samura, Hidenori Akutsu, Haruhiko Sago, Tohru Kiyono, Aikou Okamoto & Akihiro Umezawa
Stem Cell Research & Therapy volume 12, Article number: 476 (2021)
Novel Preclinical Human Salivary Gland Cancer Models Established Using Organoid Culture And Patient-Derived Xenografting
Aizawa Y, Takada K, Aoyama J, Sano D, Yamanaka S, Seki M, Kuze Y, Ramilowski J, Okuda R, Ueno Y, Nojima Y, Inayama Y, Hatakeyama H, Hatano T, Takahashi H, Nishimura G, Fujii S, Suzuki Y, Taniguchi H, Oridate N
Research Square, 03 Sep 2021
Establishment and characterization of NCC-ssRMS2-C1: a novel patient-derived cell line of spindle cell/sclerosing
Ryuto Tsuchiya, Yuki Yoshimatsu, Rei Noguchi, Yooksil Sin, Takuya Ono, Akane Sei, Fumitaka Takeshita, Jun Sugaya, Fumihiko Nakatani, Akihiko Yoshida, Seiji Ohtori, Akira Kawai & Tadashi Kondo
Human Cell volume 34, pages 1569–1578 (2021)
Inhibition of FGF10-ERK signal activation suppresses intraductal papillary neoplasm of the bile duct and its associated carcinomas
Hiroyuki Tomita, Kaori Tanaka, Akihiro Hirata, Hideshi Okada, HisashiImai, Yohei Shirakami, Kotaro Ohnishi, Shigeyuki Sugie, Hitomi Aoki, Yuichiro Hatano, Kei Noguchi, Tomohiro Kanayama, AyumiNiwa, Natsuko Suzui, Tatsuhiko Miyazaki, Takuj iTanaka, Haruhiko Akiyama. Masahito Shimizu, Kazuhiro Yoshida, Akira Hara
Cell Reports
Volume 34, Issue 8, 23 February 2021, 108772
Establishment and characterization of the NCC-GCTB4-C1 cell line: a novel patient-derived cell line from giant cell tumor of bone
Takuya Ono, Rei Noguchi, Yuki Yoshimatsu, Ryuto Tsuchiya, Yooksil Sin, Rumi Nakagawa, Kaoru Hirabayashi, Iwao Ozawa, Kazutaka
Human Cell volume 35, pages 392–399 (2022)
Establishment and characterization of NCC-LGFMS1-C1: a novel patient-derived cell line of low-grade fibromyxoid sarcoma
Yuki Yoshimatsu, Rei Noguchi, Yooksil Sin, Ryuto Tsuchiya, Takuya Ono, Akane Sei, Jun Sugaya, Shintaro Iwata, Akihiko Yoshida, Akira Kawai & Tadashi Kondo
Human Cell volume 34, pages 1919–1928 (2021)
Establishment and characterization of NCC-DDLPS1-C1: a novel patient-derived cell line of dedifferentiated liposarcoma
Rei Noguchi, Yuki Yoshimatsu, Takuya Ono, Akane Sei, Kaoru Hirabayashi, Iwao Ozawa, Kazutaka Kikuta & Tadashi Kondo
Human Cell volume 34, pages 688–697 (2021)
Establishment and characterization of novel patient-derived cell lines from giant cell tumor of bone
Yuki Yoshimatsu, Rei Noguchi, Ryuto Tsuchiya, Takuya Ono, Yooksil Sin, Sei Akane, Jun Sugaya, Tomoaki Mori, Suguru Fukushima, Akihiko Yoshida, Akira Kawai & Tadashi Kondo
Human Cell volume 34, pages 1899–1910 (2021)
Establishment and characterization of NCC-LMS2-C1—a novel patient-derived cancer cell line of leiomyosarcoma
Rei Noguchi, Yuki Yoshimatsu, Takuya Ono, Akane Sei, Kaoru Hirabayashi, Iwao Ozawa, Kazutaka Kikuta & Tadashi Kondo
Human Cell volume 34, pages 279–288 (2021)
Establishment and characterization of novel patient-derived cell lines from giant cell tumor of bone
Yuki Yoshimatsu, Rei Noguchi, Ryuto Tsuchiya, Takuya Ono, Yooksil Sin, Sei Akane, Jun Sugaya, Tomoaki Mori, Suguru Fukushima, Akihiko Yoshida, Akira Kawai & Tadashi Kondo
Human Cell volume 34, pages 1899–1910 (2021)
Core-shell hydrogel microfiber-expanded pluripotent stem cell-derived lung progenitors applicable to lung reconstruction in vivo
Satoshi Ikeo, Yuki Yamamoto, Kazuhiro Ikeda, Naoyuki Sone, Yohei Korogi, Lucia Tomiyama, Hisako Matsumoto, Toyohiro Hirai, Masatoshi Hagiwara, Shimpei Gotoh
Biomaterials Volume 276, September 2021, 121031
Establishment and Characterization of NCC-DDLPS4-C1: A Novel Patient-Derived Cell Line of Dedifferentiated Liposarcoma
Ryuto Tsuchiya, Yuki Yoshimatsu, Rei Noguchi, Yooksil Sin, Takuya Ono, Taro Akiyama, Takeshi Hirose, Shintaro Iwata, Akihiko Yoshida, Seiji Ohtori, Akira Kawai and Tadashi Kondo
J. Pers. Med. 2021, 11(11), 1075
Drug metabolism activity is a Critical Intrinsic Selector for Hepatocytes to elongate cell lifespan by using a cell-killing antibiotic
Saeko Akiyama, Noriaki Saku, Shoko Miyata, Kenta Ite, Masashi Toyoda, Tohru Kimura, Masahiko Kuroda, Atsuko Nakazawa, Mureo Kasahara, Hidenori Nonaka, Akihide Kamiya, Tohru Kiyono, Toru Kobayshi, Yasufumi Murakami, Akihiro Umezawa
bioRxiv, 19 Apr 2021
Establishment of in vitro 3D spheroid cell cultivation from human gynecologic cancer tissues
Haruka Ueda, Yutaro Mori, Kaoru Yamawaki, Tatsuya Ishiguro, Hirokazu Ohata, Ai Sato, Kentaro Sugino, Nozomi Yachida, Manako Yamaguchi, Kazuaki Suda, Ryo Tamura, Kosuke Yoshihara, Koji Okamoto, Takayuki Enomoto
STAR Protocols Volume 2, Issue 1, 19 March 2021, 100354
Kras activation in endometrial organoids drives cellular transformation and epithelial-mesenchymal transition
Yoshiaki Maru, Naotake Tanaka, Yasutoshi Tatsumi, Yuki Nakamura, Makiko Itami & Yoshitaka Hippo
Oncogenesis volume 10, Article number: 46 (2021)
Long-term selective stimulation of transplanted neural stem/progenitor cells for spinal cord injury improves locomotor function
Momotaro Kawai, Kent Imaizumi, Mitsuru Ishikawa, Shinsuke Shibata, Munehisa Shinozaki, Takahiro Shibata, Shogo Hashimoto, Takahiro Kitagawa, Kentaro Ago, Keita Kajikawa, Reo Shibata, Yasuhiro Kamata, Junichi Ushiba, Keisuke Koga, Hidemasa Furue, Morio Matsumoto, Masaya Nakamura, Narihito Nagoshi, Hideyuki Okano
Cell Reports Volume 37, Issue 8, 23 November 2021, 110019
Clinicopathological and Preclinical Patient-Derived Model Studies Define High Expression of NRN1 as a Diagnostic and Therapeutic Target for Clear Cell Renal Cell Carcinoma
Shuhei Kamada, Kazuhiro Ikeda, Takashi Suzuki, Wataru Sato, Sachi Kitayama, Satoru Kawakami, Tomohiko Ichikawa, Kuniko Horie, and Satoshi Inoue
Front Oncol. 2021; 11: 758503.
Functional inhibition of cancer stemness-related protein DPP4 rescues tyrosine kinase inhibitor resistance in renal cell carcinoma
Shuhei Kamada, Takeshi Namekawa, Kazuhiro Ikeda, Takashi Suzuki, Makoto Kagawa, Hideki Takeshita, Akihiro Yano, Koji Okamoto, Tomohiko Ichikawa, Kuniko Horie-Inoue, Satoru Kawakami & Satoshi Inoue
Oncogene volume 40, pages 3899–3913 (2021)
Malignant subclone drives metastasis of genetically and phenotypically heterogenous cell clusters through fibrotic niche generation
Sau Yee Kok, Hiroko Oshima, Kei Takahashi, Mizuho Nakayama, Kazuhiro Murakami, Hiroki R. Ueda, Kohei Miyazono & Masanobu
Nature Communications volume 12, Article number: 863 (2021)
Tumor necroptosis is correlated with a favorable immune cell signature and programmed death-ligand 1 expression in cholangiocarcinoma
Thanpisit Lomphithak, Perawatt Akara-amornthum, Keigo Murakami, Masatoshi Hashimoto, Hajime Usubuchi, Erina Iwabuchi, Michiaki Unno, Zhenyu Cai, Hironobu Sasano & Siriporn Jitkaew
Scientific Reports volume 11, Article number: 11743 (2021)
Experience with Large Panel Next-generation Sequencing in Patients with Advanced Solid Cancers at Juntendo University Hospital
TAKUO HAYASHI, SHUNSUKE KATO
Juntendo Medical Journal 2020. 66(5), 392-402
KLF4 Regulates Goblet Cell Differentiation in BMI1+ Reserve Intestinal Stem Cell Lineage during Homeostasis
Takahito Katano, Agnieszka B. Bialkowska, and Vincent W. Yang
Int J Stem Cells. 2020 Nov 30;13(3):424-431
Combination efficacy of pertuzumab and trastuzumab for trastuzumab emtansine-resistant cells exhibiting attenuated lysosomal trafficking or efflux pumps upregulation
Yoriko Yamashita-Kashima, Sei Shu, Masahiro Osada, Takaaki Fujimura, Shigeki Yoshiura, Naoki Harada & Yasushi Yoshimura
Int J Stem Cells. 2020 Nov 30;13(3):424-431
Circulation of gut-preactivated naïve CD8+ T cells enhances antitumor immunity in B cell-defective mice
Maryam Akrami , Rosemary Menzies , Kenji Chamoto , Michio Miyajima , Ryuji Suzuki , Hiroyuki Sato , Akiko Nishii , Michio Tomura , Sidonia Fagarasan , Tasuku Honjo
Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23674-23683
Immortalization of human hepatocytes from biliary atresia with CDK4R24C, cyclin D1, and TERT for cytochrome P450 induction testing
Manami Nishiwaki, Masashi Toyoda, Yoshie Oishi, Seiichi Ishida, Shin-ichiro Horiuchi, Hatsune Makino-Itou, Tohru Kimura, Shin-ichi Ohno, Takashi Ohkura, Shin Enosawa, Hidenori Akutsu, Atsuko Nakazawa, Mureo Kasahara, Tohru Kiyono & Akihiro Umezawa
Sci Rep. 2020 Oct 15;10(1):17503
(Pro)renin receptor/ATP6AP2 is required for autophagy and regulates proliferation in lung adenocarcinoma cells
Koji Ohba, Moe Endo, Shigemitsu Sato, Yurina Kashio-Yokota, Takuo Hirose, Kazuhiro Takahashi
Genes Cells. 2020 Dec;25(12):782-795
Organoid-based ex vivo reconstitution of Kras-driven pancreatic ductal carcinogenesis
Tetsuya Matsuura, Yoshiaki Maru, Masashi Izumiya, Daisuke Hoshi, Shingo Kato, Masako Ochiai, Mika Hori, Shogo Yamamoto, Kenji Tatsuno, Toshio Imai, Hiroyuki Aburatani, Atsushi Nakajima, Yoshitaka Hippo
Carcinogenesis. 2020 Jun 17;41(4):490-501
The Fragility of Cryopreserved Insulin-producing Cells Differentiated from Adipose-tissue-derived Stem Cells
Kazunori Tokuda , Tetsuya Ikemoto , Yu Saito , Katsuki Miyazaki , Shoko Yamashita , Shinichiro Yamada , Satoru Imura , Yuji Morine , Mitsuo Shimada
Cell Transplant. Jan-Dec 2020;29:963689720954798
Establishment and Molecular Phenotyping of Organoids from the Squamocolumnar Junction Region of the Uterine Cervix
Yoshiaki Maru , Akira Kawata, Ayumi Taguchi , Yoshiyuki Ishii, Satoshi Baba, Mayuyo Mori, Takeshi Nagamatsu, Katsutoshi Oda, Iwao Kukimoto, Yutaka Osuga, Tomoyuki Fujii and Yoshitaka Hippo
Cancers (Basel). 2020 Mar 15;12(3):694
Lung Adenocarcinoma Mouse Models Based on Orthotopic Transplantation of Syngeneic Tumor-Initiating Cells Expressing EpCAM, SCA-1, and Ly6d
Takashi Semba , Ryo Sato , Akiyoshi Kasuga , Kentaro Suina , Tatsuhiro Shibata , Takashi Kohno , Makoto Suzuki , Hideyuki Saya , Yoshimi Arima
Cancers (Basel). 2020 Dec 17;12(12):3805
Follistatin expressed in mechanically-damaged salivary glands of male mice induces proliferation of CD49f+ cells
A. Ikeda, T. Yamamoto, J. Mineshiba & S. Takashiba
Sci Rep. 2020 Nov 17;10(1):19959
Transient FOXO1 inhibition in pancreatic endoderm promotes the generation of NGN3+ endocrine precursors from human iPSCs
Ben Sasaki , Shinji Uemoto , Yoshiya Kawaguchi
Stem Cell Res. 2020 Apr;44:101754
Vascularized cancer on a chip: The effect of perfusion on growth and drug delivery of tumor spheroid
Yuji Nashimoto , Ryu Okada , Sanshiro Hanada , Yuichiro Arima , Koichi Nishiyama , Takashi Miura , Ryuji Yokokawa
Biomaterials. 2020 Jan;229:119547
Establishment and characterization of a novel alveolar rhabdomyosarcoma cell line, NCC-aRMS1-C1
Yooksil Sin , Yuki Yoshimatsu , Rei Noguchi , Ryuto Tsuchiya , Akane Sei , Takuya Ono , Shunichi Toki , Eisuke Kobayashi , Ayumu Arakawa , Masanaka Sugiyama , Akihiko Yoshida , Akira Kawai , Tadashi Kondo
Hum Cell. 2020 Oct;33(4):1311-1320
Establishment and characterization of NCC-ASPS1-C1: a novel patient-derived cell line of alveolar soft-part sarcoma
Yuki Yoshimatsu, Rei Noguchi, Ryuto Tsuchiya, Akane Sei, Jun Sugaya, Suguru Fukushima, Akihiko Yoshida, Akira Kawai & Tadashi
Hum Cell. 2020 Oct;33(4):1302-1310
A novel evaluation method for determining drug-induced hepatotoxicity using 3D bio-printed human liver tissue
Izumi Ide, Eri Nagao, Sakura Kajiyama & Natsumi Mizoguchi
Toxicol Mech Methods. 2020 Mar;30(3):189-196